Chemical Products Tirofiban Material and Products

CAS No:144494-65-5
Formula:C22H36N2O5S
Synonyms:TIROFIBAN;(2s)-2-(butylsulfonylamino)-3-[4-[4-(4-piperidyl)butoxy]phenyl]propanoic acid;Aggrastat;MK-383;N-(Butylsulfonyl)-O-[4-(4-piperidinyl)butyl]-L-tyrosine;C07965;Tirofiban/Tirofiban HCl;irofiban
China Export:From 2018.11 to 2019.11, total export volume of Tirofiban from China was 13,855,645KG while total export value was $145,351,813. The biggest proportion of exporting volume in the last 12 months was 13.76% in 2019.03.

Chemical Products Tirofiban Description
ChEBI: A member of the class of piperidines that is L-tyrosine in which a hydrogen attached to the amino group is replaced by a butylsulfonyl group and in which the hydrogen attached to the phenolic hydroxy group is replaced by a 4-(piperidin-4-y )butyl group.Tirofiban is a nonpeptide that appears unrelatedchemically to eptifibatide, but actually has many similarities.The chemical architecture incorporates a systemthat is mimicking the RGD moiety that is present in eptifibatide.This can be see

Chemical Products Tirofiban Basic Attributes
CAS No：144494-65-5

Molecular Formula ：C22H36N2O5S

Molecular Mass ：440.6

Exact Mass ：440.234497

PSA ：113 A^2

LogP ：1.4

EINECS ：1806241-263-5

InChIKeys ：COKMIXFXJJXBQG-NRFANRHFSA-N

H-bond Acceptor ：7

H-bond Donor ：3

SP3 ：0.68

RBN ：14

Chemical Products Tirofiban Characteristics
Density ：1.154±0.06 g/cm3(Predicted)

Melting Point ：223-225°

Bolling Point ：611.7±65.0 °C(Predicted)

Flash Point ：323.7±34.3 °C

Refractive Index ：1.532

Solubility ：H2O: Very slightly soluble

Vapor Pressure ：5.2X10-16 mmHg at 25 deg C /Estimated/

Chemical Products Tirofiban Safety Information
Packing Group ：II

Hazard Class ：8

HS Code ：2942000000

UN No. ：UN3261

WGK_Germany ：3

Risk Code ：36/37/38

Safety Instructions ：26

RTECS No. ：YP2364100

Dangerous Mark ：Xi

P Code ：P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501

Hazard Statements ：H315

Chemical Products Tirofiban Product Usage
Antithrombotic drugs. Used to treat unstable angina. Specific non-peptide platelet fibrinogen receptor (GPⅠb/Ⅲa) antagonist.

Chemical Products Tirofiban Production Methods
Compound 6 (500.0 g, 1.1 mol) and 10percent palladium on charcoal (25.0 g) was dissolved in acetic acid (5.0 liters, 5percent by weight) under the conditions of hydrogen pressure 1.50MPa and stirred at 60 ° C for 6 h. The catalyst was removed by filtration. The filtrate was concentrated to dryness, to the residue was added acetic acid (500 ml) and water (500 ml), stirred for 1 hour , filtered, a white solid (475.0 g) was obtained. Melting point: 220.0~221.5. The above solid was dissolved in ethyl formate (5.0 liters), a solution of concentrated hydrochloric acid (150 ml) was added dropwise with stirring. After stirring, the mixture was stirred at room temperature for 6 hours.filtered, the filter cake was washed with ethyl acetate and dried under vacuum at 45 ° C for 10 hours to obtain white solid 1 (516.2 g, 95.7percent).Weigh 2 · 2 g (5 mmol) of Compound 6 (500.0 g, 1.1 mol) and 10% palladium on charcoal (25.0 g) was dissolved in acetic acid (5.0 liters, 5% by weight) under the conditions of hydrogen pressure 1.50MPa and stirred at 60 C for 6 h. The catalyst was removed by filtration. The filtrate was concentrated to dryness, to the residue was added acetic acid (500 ml) and water (500 ml), stirred for 1 hour , filtered, a white solid (475.0 g) was obtained. Melting point: 220.0~221.5. The above solid was dissolved in ethyl formate (5.0 liters), a solution of concentrated hydrochloric acid (150 ml) was added dropwise with stirring. After stirring, the mixture was stirred at room temperature for 6 hours.filtered, the filter cake was washed with ethyl acetate and dried under vacuum at 45 C for 10 hours to obtain white solid 1 (516.2 g, 95.7%).Compound 6 (500.0 g, 1.1 mol) and 10% palladium on charcoal (25.0 g) was dissolved in acetic acid (5.0 liters, 5% by weight) under the conditions of hydrogen pressure 1.50MPa and stirred at 60 C for 6 h. The catalyst was removed by filtration. The filtrate was concentrated to dryness, to the residue was added acetic acid (500 ml) and water (500 ml), stirred for 1 hour , filtered, a white solid (475.0 g) was obtained.

Chemical Products Tirofiban Material and Products
Material ：
N-Butyllithium, Tetrahydrofuran, N-Butylsulfonyl-O-(4-(4-pyridinyl)butyl)-L-tyrosine, Potassiumbisulfate, 4-Methylpyridine, L-Tyrosine, N-Methylacetamide, 1-Bromo-3-chloropropane