Tramadol 50 mg capsule is an oral medication used to relieve moderate to moderately severe ongoing pain. Tramadol is similar to opioid (narcotic) pain relievers. It works in the brain to change the way your body feels and responds to pain.
Tramadol is an oral narcotic-like pain medication used as a treatment for moderate to severe pain in adults.
The extended-release tablet formulation of this drug is used for the treatment of moderate to severe chronic pain when around-the-clock treatment is needed. This medicine must be prescribed by a doctor and is available only by prescription.
Patients taking this drug should warn their doctors of any problems due to using this drug and of any unusual side effects or symptoms or bothersome side effects.
Care should be taken to ensure that this drug is taken exactly as prescribed.
The risk of dependence on most opioid drugs is generally high. However, the risk of Tramadol 50 mg capsule addiction is not high. Read the patient health information leaflet that came with your prescription for this medicine, as well as each time you get a refill. There may be new information on health care.
Why it’s used
Tramadol is used to treat moderate to severe pain.
Tramadol can be used as part of a combination therapy. This means you may need to take it with other medications.
How it works
Tramadol is in a class of drugs called opioid agonists. A drug class is a group of drugs that work in a similar way. These drugs are often used to treat similar conditions.
Tramadol works by changing the way the brain detects pain. Tramadol is similar to substances in the brain called endorphins. Endorphins bind to receptors (parts of cells that receive a certain substance). The receptors then decrease the pain messages your body sends to your brain. Tramadol works in a similar way to reduce the amount of pain your brain thinks you are having.
Proper Use
Take this medicine only as directed by your doctor. Do not take more, do not take more often, and do not take longer than prescribed by your doctor. If too much of this drug is taken for a long time, it can cause addiction (causing mental or physical dependence) or cause an overdose.
It is very important to understand the rules of the REMS opioid analgesic program to prevent addiction, abuse and misuse of the combination of paracetamol and codeine. This drug must be accompanied by a drug guide. Read and follow the instructions carefully. Please re-read it each time you receive a top-up in case there is new information. Ask your doctor if you have any questions.
If you think this medicine does not work well after taking it for a few weeks, do not increase the dose. Instead, check with your doctor. If you are using the disintegrating tablet, make sure your hands are dry before handling it. Do not open the blister containing the tablet until you are ready to take it. Remove the tablet from the blister by peeling off the foil and taking out the tablet. Do not push the tablet through the foil. Don’t break it, crush it, or chew it. Put the tablet in your mouth. It should melt quickly. After the tablet has dissolved, swallow or take a sip of water.
Swallow the prolonged-release capsule, the prolonged-release tablet and the whole tablet with liquid. Do not break it, crush it, chew it, inhale it or inject it.
Dosing information:-
Usual adult dose for pain:
Adults (17 years and older): 50 to 100 mg orally every 4 to 6 hours as needed for pain
– For patients who do not require a rapid onset of analgesic effect: Initial dose: 25 mg orally once a day; titrate in increments of 25 mg every 3 days to 25 mg four times a day; thereafter increase by 50 mg as tolerated every 3 days
Maximum dose: 400 mg per day.
Usual adult dose for chronic pain:
Extended release (ER):
18 years or older (tramadol naive): 100 mg orally once daily
– Titrate individually in 100 mg increments every 5 days to an effective dose that minimizes adverse reactions
-Maximum dose: 300 mg / day
For patients CURRENTLY receiving immediate-release (IR) tramadol:
Starting Dose: Calculate 24-hour IR requirement and start with a total daily dose of ER rounded down to the next smaller increment of 100 mg orally once daily
Conversion from other opioids:
Discontinue all other opioid medications for the whole day before starting therapy
– Starting dose: 100 mg ER PO once daily
– Titrate individually in 100 mg increments every 5 days to an effective dose that minimizes adverse reactions
-Maximum dose: 300 mg / day.
Usual geriatric dose for pain:
Dose selection should be cautious, usually starting at the lower end of the dosing range.
Over 75 years: Maximum immediate release dose: 300 mg per day.
Usual geriatric dose for chronic pain:
Dose selection should be cautious, usually starting at the lower end of the dosing range.
Over 75 years:
Maximum immediate release dose: 300 mg per day.
Usual Pediatric Dose for Pain:
The use of tramadol in pediatric patients is not recommended.
17 years and older: see adult dose.
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Side effects
Side effects associated with use of Tramadol, include the following:
- constipation
- nausea
- dizziness
- vertigo
- headache
- drowsiness
- vomiting
- agitation
- anxiety
- mood swings
- euphoria
- hallucinations
- nervousness
- muscle spasms or stiffness
- indigestion
- weakness
- itching
- diarrhea
- dry mouth
- sweating
- feeling unwell (malaise)
- menopausal symptoms
- rash
- urinary frequency
- urinary retention
- dilation of blood vessels (vasodilation)
- visual disturbances
- abnormal gait
- amnesia
- cognitive dysfunction
- depression
- difficulty in concentration
- feeling uneasy
- painful urination
- fatigue
- menstrual dysphoric disorder
- motor system weakness
- lightheadedness upon standing (orthostatic hypotension)
- numbness and tingling
- seizures
- suicidal tendencies
- fainting (syncope)
- fast heart rate
- tremors
- abnormal electrocardiogram (ECG)
- swelling (angioedema)
- cough
- flushing
- high blood pressure (hypertension)
- low blood pressure (hypotension), may be severe
- reduced blood flow to the heart (myocardial ischemia)
- palpitations
- hives
- withdrawal syndrome
- life threatening respiratory depression
- neonatal opioid withdrawal syndrome
- adrenal insufficiency
- abdominal pain
- serotonin syndrome
- severe allergic reaction (anaphylaxis)
- androgen deficiency
Warnings
This drug contains tramadol. Do not take Ultram, Ultram ER, Ryzolt or ConZip if you are allergic to tramadol or any of the other ingredients of this medicine.
Keep out of reach of children. In the event of an overdose, consult a physician or contact a Poison Information Center immediately.
Contraindications
Contraindications include hypersensitivity to tramadol or opioids. Known or suspected gastrointestinal obstruction, including paralytic effects. Simultaneous use of monoamine oxidase inhibitors (MAOIs) or use within the past 14 days.
Effects of drug abuse
Risk of fuel addiction, abuse and misuse of opioids, which can lead to overdose and death; assess each patient’s risk before prescribing and regularly monitor all patients for the development of these behaviors or conditions.
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